Version 5.4
Mus musculus Gene: Zhx3
Summary
InnateDB Gene IDBG-211647.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zhx3
Gene Name zinc fingers and homeoboxes 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000035877
Encoded Proteins
IDBP-211649
zinc fingers and homeoboxes 3
IDBP-211651
zinc fingers and homeoboxes 3
IDBP-262345
zinc fingers and homeoboxes 3
IDBP-533025
zinc fingers and homeoboxes 3
IDBP-719694
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174306:
This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:160748708-160872998
Strand Reverse strand
Band H2
Transcripts
ENSMUST00000103112 ENSMUSP00000099401
ENSMUST00000103111 ENSMUSP00000099400
ENSMUST00000109460 ENSMUSP00000105086
ENSMUST00000154038
ENSMUST00000133937
ENSMUST00000127201 ENSMUSP00000120488
ENSMUST00000176141 ENSMUSP00000134763
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030154 cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005938 cell cortex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000174306
View Gene Order
ENSBTAG00000017594
Not yet available
Cross-References
SwissProt Q8C0Q2
TrEMBL F6V503 H3BIX6 Q3UPQ8
UniProt Splice Variant
Entrez Gene 320799
UniGene Mm.436734 Mm.437998 Mm.489808
RefSeq NM_177263
OMIM
CCDS CCDS16997
HPRD
IMGT
MGI ID MGI:2444772
MGI Symbol Zhx3
EMBL AB099527 AB099703 AK030057 AK122271 AK143296 AL590389 BC058111 CH466551 DQ317973
GenPept AAH58111 ABC47790 BAC26763 BAC65553 BAC87711 BAC87741 BAE25337 EDL06293 EDL06295 EDL06296
RNA Seq Atlas 320799

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca