InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp6v0a1

Summary

InnateDB Protein

IDBP-211719.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v0a1

Protein Name

ATPase, H+ transporting, lysosomal V0 subunit A1

Synonyms

AA959968; ATP6a1; Atp6n1; Atp6n1a; Atpv0a1; Vpp-1; Vpp1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044838

InnateDB Gene

IDBG-211715 (Atp6v0a1)

Protein Structure

UniProt Annotation

Function

Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome {ECO:0000250}. Note=Coated vesicle.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0051117	ATPase binding

Biological Process

GO:0015991

ATP hydrolysis coupled proton transport

Cellular Component

GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain
GO:0042470	melanosome
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome