InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: L3mbtl1

Summary

InnateDB Protein

IDBP-211791.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

L3mbtl1

Protein Name

l(3)mbt-like (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044038

InnateDB Gene

IDBG-211789 (L3mbtl1)

Protein Structure

UniProt Annotation

Function

Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post- translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain, testis, eyes, and ES cells. {ECO:0000269PubMed:20592034}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031491	nucleosome binding
GO:0031493	nucleosomal histone binding
GO:0032093	SAM domain binding
GO:0035064	methylated histone binding
GO:0042393	histone binding
GO:0042802	identical protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007088	regulation of mitosis
GO:0016568	chromatin modification
GO:0030097	hemopoiesis
GO:0040029	regulation of gene expression, epigenetic
GO:0045652	regulation of megakaryocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0000785	chromatin
GO:0000793	condensed chromosome
GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

MGI:2676663

InterPro

IPR001660 Sterile alpha motif domain
IPR002515 Zinc finger, C2HC-type
IPR004092 Mbt repeat
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF01530
PF02820
PF00536

PRINTS

PIRSF

SMART

SM00454
SM00561

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A2A5N8