Version 5.4
Mus musculus Protein: Psmc3ip
Summary
InnateDB Protein IDBP-211836.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psmc3ip
Protein Name proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
Synonyms C79099; GT198; HOP2; Tbpip;
Species Mus musculus
Ensembl Protein ENSMUSP00000019447
InnateDB Gene IDBG-211834 (Psmc3ip)
Protein Structure
UniProt Annotation
Function Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1- promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. {ECO:0000269PubMed:15192114, ECO:0000269PubMed:16675459, ECO:0000269PubMed:17426123, ECO:0000269PubMed:17639080, ECO:0000269PubMed:17639081, ECO:0000269PubMed:9345291}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11739747}.
Disease Associations
Tissue Specificity Highly expressed in testis and more specifically in spermatocytes. Detected in spleen, ovary and thymus. {ECO:0000269PubMed:11739747, ECO:0000269PubMed:9345291}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
Biological Process
GO:0006310 DNA recombination
GO:0007126 meiotic nuclear division
GO:0045892 negative regulation of transcription, DNA-templated
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1098610
InterPro IPR005650 BlaI transcriptional regulatory family
IPR010776 Tat binding protein 1-interacting
PFAM PF03965
PF07106
PRINTS
PIRSF PIRSF019455
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35047
PhosphoSite PhosphoSite-
TrEMBL C4PFH6
UniProt Splice Variant
Entrez Gene 19183
UniGene
RefSeq NP_032975
MGI ID 2MH2
MGI Symbol Psmc3ip
OMIM
CCDS CCDS25448
HPRD
IMGT
EMBL AB000121 AK133462 BC030169 BX255926 CH466677 FJ937966 FJ937967
GenPept AAH30169 ACR24246 ACR24247 BAA23155 BAE21670 CAM24469 EDL03884

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca