InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tubg1

Summary

InnateDB Protein

IDBP-211871.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tubg1

Protein Name

tubulin, gamma 1

Synonyms

1500010O08Rik; AI451582; AI503389; Tubg;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048036

InnateDB Gene

IDBG-211869 (Tubg1)

Protein Structure

UniProt Annotation

Function

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:19648910}. Note=Mainly localizes to the centrosome, but a fraction is found outside of the centrosome in the cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000212	meiotic spindle organization
GO:0006184	GTP catabolic process
GO:0007020	microtubule nucleation
GO:0007052	mitotic spindle organization
GO:0007088	regulation of mitosis
GO:0031122	cytoplasmic microtubule organization
GO:0051258	protein polymerization

Cellular Component

GO:0000242	pericentriolar material
GO:0000794	condensed nuclear chromosome
GO:0000922	spindle pole
GO:0000930	gamma-tubulin complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005814	centriole
GO:0005815	microtubule organizing center
GO:0005827	polar microtubule
GO:0005876	spindle microtubule
GO:0005881	cytoplasmic microtubule
GO:0005929	cilium
GO:0031252	cell leading edge
GO:0031513	nonmotile primary cilium
GO:0036064	ciliary basal body
GO:0043234	protein complex
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

MGI:101834

InterPro

IPR000217 Tubulin
IPR002452 Alpha tubulin
IPR002453 Beta tubulin
IPR002454 Gamma tubulin
IPR002967 Delta tubulin
IPR003008 Tubulin/FtsZ, GTPase domain
IPR004057 Epsilon tubulin
IPR008280 Tubulin/FtsZ, C-terminal
IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
IPR019605 Misato Segment II tubulin-like domain

PFAM

PF00091
PF03953
PF10644

PRINTS

PR01161
PR01162
PR01163
PR01164
PR01224
PR01519

PIRSF

SMART

SM00864
SM00865

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt