InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccr10

Summary

InnateDB Protein

IDBP-211912.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccr10

Protein Name

chemokine (C-C motif) receptor 10

Synonyms

Cmkbr9; Gpr2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062588

InnateDB Gene

IDBG-211910 (Ccr10)

Protein Structure

UniProt Annotation

Function

Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed at high levels in small intestine, colon, lymph nodes, Peyer patches and at lower levels in thymus, lung and spleen. {ECO:0000269PubMed:10781587}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0016493	C-C chemokine receptor activity

Biological Process

GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0070098	chemokine-mediated signaling pathway