InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ccr10

Summary

InnateDB Gene

IDBG-211910.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccr10

Gene Name

chemokine (C-C motif) receptor 10

Synonyms

Cmkbr9; Gpr2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000044052

Encoded Proteins

IDBP-211912

chemokine (C-C motif) receptor 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184451:
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:101172997-101175443

Strand

Reverse strand

Band

Transcripts

ENSMUST00000062759

ENSMUSP00000062588

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0016493	C-C chemokine receptor activity

Biological Process

GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0070098	chemokine-mediated signaling pathway