InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ifitm3

Summary

InnateDB Protein

IDBP-211942.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ifitm3

Protein Name

interferon induced transmembrane protein 3

Synonyms

1110004C05Rik; Cd225; Cdw217; DSPA2b; Fgls; IP15; mil-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026565

InnateDB Gene

IDBG-211940 (Ifitm3)

Protein Structure

UniProt Annotation

Function

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV) and human immunodeficiency virus type 1 (HIV-1). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. Involved in initiating germ cell competence and specification, and in the demarcation of PGCs from their somatic neighbors. {ECO:0000269PubMed:12124616, ECO:0000269PubMed:18505827, ECO:0000269PubMed:21253575, ECO:0000269PubMed:22467717}.

Subcellular Localization

Cell membrane; Single-pass type II membrane protein. Late endosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in acinar cell. Predominantly expressed in nascent primordial germ cells, as well as in gonadal germ cells. {ECO:0000269PubMed:12659663, ECO:0000269PubMed:15184081}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007507	heart development
GO:0008285	negative regulation of cell proliferation
GO:0009607	response to biotic stimulus
GO:0009615	response to virus
GO:0046597	negative regulation of viral entry into host cell
GO:0051607	defense response to virus
GO:0055007	cardiac muscle cell differentiation
GO:0060337	type I interferon signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0031902	late endosome membrane
GO:0045177	apical part of cell