InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ezh1

Summary

InnateDB Protein

IDBP-211958.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ezh1

Protein Name

enhancer of zeste homolog 1 (Drosophila)

Synonyms

ENX-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097984

InnateDB Gene

IDBG-211954 (Ezh1)

Protein Structure

UniProt Annotation

Function

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269PubMed:19026780}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Colocalizes with trimethylated 'Lys-27' of histone H3. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in kidney, adrenal gland, testis and brain. {ECO:0000269PubMed:9473645}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0046976	histone methyltransferase activity (H3-K27 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0070734	histone H3-K27 methylation