Version 5.4
Mus musculus Protein: Ptdss2
Summary
InnateDB Protein IDBP-212009.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptdss2
Protein Name phosphatidylserine synthase 2
Synonyms AI481134; AI988017; PSS2;
Species Mus musculus
Ensembl Protein ENSMUSP00000026568
InnateDB Gene IDBG-212007 (Ptdss2)
Protein Structure
UniProt Annotation
Function Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine. {ECO:0000269PubMed:10432300}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:10938271}; Multi-pass membrane protein {ECO:0000269PubMed:10938271}. Note=Highly enriched in the mitochondria-associated membrane (MAM).
Disease Associations
Tissue Specificity Highly expressed in testis. Detected at lower levels in kidney and heart. {ECO:0000269PubMed:10432300, ECO:0000269PubMed:12361952}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity
Biological Process
GO:0006659 phosphatidylserine biosynthetic process
Cellular Component
GO:0005622 intracellular
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1351664
InterPro IPR004277 Phosphatidyl serine synthase
PFAM PF03034
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z1X2
PhosphoSite PhosphoSite-Q9Z1X2
TrEMBL
UniProt Splice Variant
Entrez Gene 27388
UniGene Mm.293591
RefSeq NP_038810
MGI ID
MGI Symbol Ptdss2
OMIM
CCDS CCDS22001
HPRD
IMGT
EMBL AF099053 AK021249 AK031906 AK032686 AK036368 AK081275 BC009013 BC053517
GenPept AAC98383 AAH09013 AAH53517 BAB32347 BAC27599 BAC27987 BAC29399 BAC38180

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca