InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD276

Summary

InnateDB Protein

IDBP-21201.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD276

Protein Name

CD276 molecule

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000320058

InnateDB Gene

IDBG-21197 (CD276)

Protein Structure

UniProt Annotation

Function

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269PubMed:11224528, ECO:0000269PubMed:12906861, ECO:0000269PubMed:14764704, ECO:0000269PubMed:15314238, ECO:0000269PubMed:15682454, ECO:0000269PubMed:15961727}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. {ECO:0000269PubMed:11224528, ECO:0000269PubMed:14764704, ECO:0000269PubMed:15961727, ECO:0000269PubMed:16049332, ECO:0000269PubMed:16274630}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0008283	cell proliferation
GO:0042102	positive regulation of T cell proliferation
GO:0042110	T cell activation
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0050776	regulation of immune response

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003597 Immunoglobulin C1-set
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07654
PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00406
SM00407
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5ZPR3