Version 5.4
Mus musculus Protein: Stk4
Summary
InnateDB Protein IDBP-212023.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Stk4
Protein Name serine/threonine kinase 4
Synonyms AI447339; AU020804; Kas-2; Mst1; Ysk3;
Species Mus musculus
Ensembl Protein ENSMUSP00000085629
InnateDB Gene IDBG-212019 (Stk4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004674 protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0000902 cell morphogenesis
GO:0001569 patterning of blood vessels
GO:0001841 neural tube formation
GO:0003157 endocardium development
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007417 central nervous system development
GO:0008285 negative regulation of cell proliferation
GO:0023014 signal transduction by phosphorylation
GO:0030216 keratinocyte differentiation
GO:0035329 hippo signaling
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0046621 negative regulation of organ growth
GO:0046777 protein autophosphorylation
GO:0060215 primitive hemopoiesis
GO:0060706 cell differentiation involved in embryonic placenta development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097284 hepatocyte apoptotic process
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1929004
InterPro IPR011524 SARAH domain
IPR024205 Mst1 SARAH domain
PFAM PF11629
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q8CDG4
UniProt Splice Variant
Entrez Gene 58231
UniGene Mm.490677
RefSeq
MGI ID
MGI Symbol Stk4
OMIM
CCDS
HPRD
IMGT
EMBL AK030098 AL591512 AL591542
GenPept BAC26783

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca