InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vat1

Summary

InnateDB Protein

IDBP-212203.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vat1

Protein Name

vesicle amine transport protein 1 homolog (T californica)

Synonyms

VAT-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048350

InnateDB Gene

IDBG-212201 (Vat1)

Protein Structure

UniProt Annotation

Function

Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. Note=The majority is localized in the cytoplasm a small amount is associated with mitochondria. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

Biological Process

GO:0010637	negative regulation of mitochondrial fusion
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005741	mitochondrial outer membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1349450

InterPro

IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013154 Alcohol dehydrogenase GroES-like
IPR020843 Polyketide synthase, enoylreductase

PFAM

PF00107
PF08240

PRINTS

PIRSF

SMART

SM00829

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q62465