Version 5.4
Mus musculus Protein: Pigt
Summary
InnateDB Protein IDBP-212209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pigt
Protein Name phosphatidylinositol glycan anchor biosynthesis, class T
Synonyms 2510012P17Rik; 4930534E15Rik; CGI-06; NDAP; Ndap7;
Species Mus musculus
Ensembl Protein ENSMUSP00000099390
InnateDB Gene IDBG-212207 (Pigt)
Protein Structure
UniProt Annotation
Function Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003923 GPI-anchor transamidase activity
GO:0005515 protein binding
Biological Process
GO:0016255 attachment of GPI anchor to protein
GO:0030182 neuron differentiation
GO:0051402 neuron apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0042765 GPI-anchor transamidase complex
Protein Structure and Domains
PDB ID MGI:1926178
InterPro IPR007245 GPI transamidase component PIG-T
PFAM PF04113
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BXQ2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 78928
UniGene Mm.28228
RefSeq NP_598540
MGI ID
MGI Symbol Pigt
OMIM
CCDS CCDS17038
HPRD
IMGT
EMBL AB057593 AF361435 AJ308886 AK044499 AK155057 AL591478 BC034175
GenPept AAH34175 AAK32809 BAB39711 BAC31951 BAE33018 CAC34729 CAM15012

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca