Version 5.4
Mus musculus Protein: Wfdc2
Summary
InnateDB Protein IDBP-212229.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wfdc2
Protein Name WAP four-disulfide core domain 2
Synonyms 1600023A02Rik; HE4; WAP5;
Species Mus musculus
Ensembl Protein ENSMUSP00000017867
InnateDB Gene IDBG-212227 (Wfdc2)
Protein Structure
UniProt Annotation
Function Broad range protease inhibitor. {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0008150 biological_process
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1914951
InterPro IPR008197 Whey acidic protein-type 4-disulphide core
PFAM PF00095
PRINTS PR00003
PIRSF
SMART SM00217
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DAU7
PhosphoSite PhosphoSite-
TrEMBL Q4FZJ6
UniProt Splice Variant
Entrez Gene 67701
UniGene
RefSeq NP_080599
MGI ID
MGI Symbol Wfdc2
OMIM
CCDS CCDS17040
HPRD
IMGT
EMBL AF334269 AK005519 BC099427
GenPept AAH99427 AAL73189 BAB24094

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca