Version 5.4
Mus musculus Gene: Wfdc2
Summary
InnateDB Gene IDBG-212227.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wfdc2
Gene Name WAP four-disulfide core domain 2
Synonyms 1600023A02Rik; HE4; WAP5
Species Mus musculus
Ensembl Gene ENSMUSG00000017723
Encoded Proteins
IDBP-212229
WAP four-disulfide core domain 2
IDBP-262586
WAP four-disulfide core domain 2
IDBP-262588
WAP four-disulfide core domain 2
IDBP-534529
WAP four-disulfide core domain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101443:
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:164562413-164568510
Strand Forward strand
Band H3
Transcripts
ENSMUST00000017867 ENSMUSP00000017867
ENSMUST00000109345 ENSMUSP00000104969
ENSMUST00000109344 ENSMUSP00000104968
ENSMUST00000146270
ENSMUST00000125051 ENSMUSP00000119391
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0008150 biological_process
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101443
View Gene Order
ENSBTAG00000013928
Not yet available
Cross-References
SwissProt Q9DAU7
TrEMBL A2A5G4 A2A5G5 A2A5G6 Q4FZJ6
UniProt Splice Variant
Entrez Gene 67701
UniGene
RefSeq NM_026323 XM_006500087
OMIM
CCDS CCDS17040
HPRD
IMGT
MGI ID MGI:1914951
MGI Symbol Wfdc2
EMBL AF334269 AK005519 AL591478 BC099427
GenPept AAH99427 AAL73189 BAB24094
RNA Seq Atlas 67701

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca