InnateDB Protein
|
IDBP-212237.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Pnpla2
|
Protein Name
|
patatin-like phospholipase domain containing 2
|
Synonyms
|
0610039C21Rik; 1110001C14Rik; Atgl; TTS-2.2;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000065116
|
InnateDB Gene
|
IDBG-212233 (Pnpla2)
|
Protein Structure
|
|
Function |
Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. {ECO:0000269PubMed:15337759, ECO:0000269PubMed:15550674, ECO:0000269PubMed:16150821, ECO:0000269PubMed:16675698, ECO:0000269PubMed:16679289, ECO:0000269PubMed:17074755}.
|
Subcellular Localization |
Lipid droplet. Cell membrane; Single-pass type II membrane protein.
|
Disease Associations |
|
Tissue Specificity |
Expressed at high levels in white and brown adipose tissue, and to a lesser degree in testis and cardiac muscle. Barely detected in liver, spleen, thymus, kidney, skeletal muscle, and brain. Among the white adipose depots, gonadal fat showed the highest level of expression compared with inguinal and renal white adipose tissues. {ECO:0000269PubMed:15337759, ECO:0000269PubMed:15550674, ECO:0000269PubMed:16150821, ECO:0000269PubMed:16705060}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
6 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1914103
|
InterPro |
IPR002641
Patatin/Phospholipase A2-related
IPR016035
Acyl transferase/acyl hydrolase/lysophospholipase
|
PFAM |
PF01734
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8BJ56
|
PhosphoSite |
PhosphoSite-Q8BJ56
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
66853
|
UniGene |
|
RefSeq |
NP_080078
|
MGI ID |
|
MGI Symbol |
Pnpla2
|
OMIM |
|
CCDS |
CCDS22015
|
HPRD |
|
IMGT |
|
EMBL |
AK002826
AK003207
AK031609
AK150184
AY510273
AY731699
AY894805
BC019188
BC044781
BC064747
U89431
|
GenPept |
AAC36536
AAH19188
AAH44781
AAH64747
AAS48458
AAU33824
AAW81963
BAB22387
BAB22643
BAC27476
BAE29364
|
|
|