Version 5.4
Mus musculus Gene: Pnpla2
Summary
InnateDB Gene IDBG-212233.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pnpla2
Gene Name patatin-like phospholipase domain containing 2
Synonyms 0610039C21Rik; 1110001C14Rik; Atgl; TTS-2.2
Species Mus musculus
Ensembl Gene ENSMUSG00000025509
Encoded Proteins
IDBP-212235
patatin-like phospholipase domain containing 2
IDBP-212237
patatin-like phospholipase domain containing 2
IDBP-626961
patatin-like phospholipase domain containing 2
IDBP-626968
patatin-like phospholipase domain containing 2
IDBP-626970
patatin-like phospholipase domain containing 2
IDBP-626972
patatin-like phospholipase domain containing 2
IDBP-626974
patatin-like phospholipase domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177666:
This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:141455198-141460743
Strand Forward strand
Band F5
Transcripts
ENSMUST00000026583 ENSMUSP00000026583
ENSMUST00000064151 ENSMUSP00000065116
ENSMUST00000164016 ENSMUSP00000127149
ENSMUST00000169665 ENSMUSP00000127983
ENSMUST00000164924 ENSMUSP00000129632
ENSMUST00000165487 ENSMUSP00000132038
ENSMUST00000169723 ENSMUSP00000126098
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004806 triglyceride lipase activity
GO:0005515 protein binding
Biological Process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0010891 negative regulation of sequestering of triglyceride
GO:0010898 positive regulation of triglyceride catabolic process
GO:0019433 triglyceride catabolic process
GO:0019915 lipid storage
GO:0034389 lipid particle organization
Cellular Component
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000177666
View Gene Order
ENSBTAG00000005144
Not yet available
Pathways
NETPATH
REACTOME
REACT_199036
Acyl chain remodeling of DAG and TAG pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
mmu00561
Glycerolipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121122
Acyl chain remodeling of DAG and TAG pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00561
Glycerolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H3BIT5
UniProt Splice Variant
Entrez Gene 66853
UniGene
RefSeq NM_001163689 NM_025802
OMIM
CCDS CCDS22015 CCDS52445
HPRD
IMGT
MGI ID MGI:1914103
MGI Symbol Pnpla2
EMBL AC102547
GenPept
RNA Seq Atlas 66853

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca