InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnnc2

Summary

InnateDB Protein

IDBP-212331.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnnc2

Protein Name

troponin C2, fast

Synonyms

Tncs;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099384

InnateDB Gene

IDBG-212329 (Tnnc2)

Protein Structure

UniProt Annotation

Function

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Subcellular Localization

Disease Associations

Tissue Specificity

Fast skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005509	calcium ion binding

Biological Process

GO:0003009	skeletal muscle contraction
GO:0007165	signal transduction

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005861	troponin complex

Protein Structure and Domains

PDB ID

MGI:98780

InterPro

IPR002048 EF-hand domain
IPR019577 SPARC/Testican, calcium-binding domain

PFAM

PF00036
PF13202
PF13405
PF10591

PRINTS

PIRSF

SMART

SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P20801

PhosphoSite

PhosphoSite-P20801

TrEMBL

UniProt Splice Variant

Entrez Gene

21925

UniGene

RefSeq

NP_033420

MGI ID

MGI Symbol

Tnnc2

OMIM

CCDS

CCDS17056

HPRD

IMGT

EMBL

BC024390 M57590

GenPept

AAA37642 AAH24390