InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctsa

Summary

InnateDB Protein

IDBP-212385.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctsa

Protein Name

cathepsin A

Synonyms

AU019505; PPCA; Ppgb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099381

InnateDB Gene

IDBG-212379 (Ctsa)

Protein Structure

UniProt Annotation

Function

Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004185	serine-type carboxypeptidase activity
GO:0005515	protein binding

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005764	lysosome

Protein Structure and Domains

PDB ID

MGI:97748

InterPro

IPR001563 Peptidase S10, serine carboxypeptidase
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00450

PRINTS

PR00724

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P16675

PhosphoSite

PhosphoSite-

TrEMBL

Q544R6

UniProt Splice Variant

Entrez Gene

19025

UniGene

Mm.359633

RefSeq

MGI ID

MGI Symbol

Ctsa

OMIM

CCDS

CCDS17062

HPRD

IMGT

EMBL

AK032197 AK159150 AK159766 AL591495 BC018534 CH466551 J05261

GenPept

AAA39982 AAH18534 BAC27752 BAE34857 BAE35356 EDL06428