InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc12a5

Summary

InnateDB Protein

IDBP-212480.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc12a5

Protein Name

solute carrier family 12, member 5

Synonyms

KCC2; mKIAA1176;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096690

InnateDB Gene

IDBG-212478 (Slc12a5)

Protein Structure

UniProt Annotation

Function

Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.

Subcellular Localization

Cell projection, dendrite {ECO:0000269PubMed:11395011}. Cell membrane {ECO:0000269PubMed:11395011}; Multi-pass membrane protein {ECO:0000269PubMed:11395011}. Note=Detected on dendrites, but not on axons of spinal cord neurons and at GPHN-positive inhibitory synapses.

Disease Associations

Tissue Specificity

Isoform 2 expressed in brainstem and spinal cord, isoform 1 expressed in brainstem, spinal cord and olfactory bulb of E17 embryos. Isoforms 1 and 2 expressed in all parts of the brain and spinal cord in postnatal day 14 mice. {ECO:0000269PubMed:17715129}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015377	cation:chloride symporter activity
GO:0015379	potassium:chloride symporter activity
GO:0019901	protein kinase binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0006821	chloride transport
GO:0007268	synaptic transmission
GO:0007612	learning
GO:0035264	multicellular organism growth
GO:0040040	thermosensory behavior
GO:0042493	response to drug
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport