InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc12a5

Summary

InnateDB Gene

IDBG-212478.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc12a5

Gene Name

solute carrier family 12, member 5

Synonyms

KCC2; mKIAA1176

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017740

Encoded Proteins

IDBP-212480

solute carrier family 12, member 5

IDBP-540636

solute carrier family 12, member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124140:
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:164960816-164999727

Strand

Forward strand

Band

Transcripts

ENSMUST00000099092	ENSMUSP00000096690
ENSMUST00000124372	ENSMUSP00000123682
ENSMUST00000135918
ENSMUST00000137302

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015377	cation:chloride symporter activity
GO:0015379	potassium:chloride symporter activity
GO:0019901	protein kinase binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0006821	chloride transport
GO:0007268	synaptic transmission
GO:0007612	learning
GO:0035264	multicellular organism growth
GO:0040040	thermosensory behavior
GO:0042493	response to drug
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000124140

View Gene Order

ENSBTAG00000014179

Not yet available

Pathways

NETPATH

REACTOME

REACT_247550

SLC-mediated transmembrane transport pathway

REACT_251788

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_253400

Transmembrane transport of small molecules pathway

REACT_247880

Cation-coupled Chloride cotransporters pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19315

Cation-coupled Chloride cotransporters pathway

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q91V14

TrEMBL

Q6PFC8

UniProt Splice Variant

Entrez Gene

57138

UniGene

Mm.252987

RefSeq

NM_020333 XM_006499943 XM_006499944

OMIM

CCDS

CCDS38332

HPRD

IMGT

MGI ID

MGI:1862037

MGI Symbol

Slc12a5

EMBL

AF332063 AF332064 AJ011033 AK122460 AK147262 AL591495 BC054808 BC057624

GenPept

AAH54808 AAH57624 AAK56092 AAK56093 BAC65742 BAE27805 CAA09464 CAM26466

RNA Seq Atlas

57138