InnateDB Protein
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IDBP-212503.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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G6pc3
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Protein Name
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glucose 6 phosphatase, catalytic, 3
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Synonyms
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0710001K01Rik; AU019276; AU045429; AV128920; AW545836; UGRP;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000064276
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InnateDB Gene
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IDBG-212501 (G6pc3)
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Protein Structure
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Function |
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function. {ECO:0000269PubMed:15087461, ECO:0000269PubMed:15661744, ECO:0000269PubMed:17023421, ECO:0000269PubMed:17318259}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Highly expressed in heart, brain, kidney and testis and to a lower extent in lung, spleen, stomach, small intestine, skeletal muscle and uterus. Expressed in muscle, brain, thymus, lung, kidney, spleen and pancreas (at protein level). {ECO:0000269PubMed:14765991, ECO:0000269PubMed:15087461, ECO:0000269PubMed:15661744}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1915651
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InterPro |
IPR000326
Phosphatidic acid phosphatase type 2/haloperoxidase
IPR016275
Glucose-6-phosphatase
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PFAM |
PF01569
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PRINTS |
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PIRSF |
PIRSF000905
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SMART |
SM00014
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TIGRFAMs |
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Modification |
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SwissProt |
Q6NSQ9
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PhosphoSite |
PhosphoSite-Q6NSQ9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
68401
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UniGene |
Mm.22385
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RefSeq |
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MGI ID |
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MGI Symbol |
G6pc3
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OMIM |
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CCDS |
CCDS25491
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HPRD |
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IMGT |
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EMBL |
AK165395
AL954730
AY186239
BC069959
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GenPept |
AAH69959
AAO39164
BAE38159
CAM25070
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