Version 5.4
Mus musculus Protein: G6pc3
Summary
InnateDB Protein IDBP-212505.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol G6pc3
Protein Name glucose 6 phosphatase, catalytic, 3
Synonyms 0710001K01Rik; AU019276; AU045429; AV128920; AW545836; UGRP;
Species Mus musculus
Ensembl Protein ENSMUSP00000077995
InnateDB Gene IDBG-212501 (G6pc3)
Protein Structure
UniProt Annotation
Function Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function. {ECO:0000269PubMed:15087461, ECO:0000269PubMed:15661744, ECO:0000269PubMed:17023421, ECO:0000269PubMed:17318259}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Highly expressed in heart, brain, kidney and testis and to a lower extent in lung, spleen, stomach, small intestine, skeletal muscle and uterus. Expressed in muscle, brain, thymus, lung, kidney, spleen and pancreas (at protein level). {ECO:0000269PubMed:14765991, ECO:0000269PubMed:15087461, ECO:0000269PubMed:15661744}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004346 glucose-6-phosphatase activity
Biological Process
GO:0006094 gluconeogenesis
GO:0006796 phosphate-containing compound metabolic process
GO:0015760 glucose-6-phosphate transport
GO:0016311 dephosphorylation
GO:0051156 glucose 6-phosphate metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1915651
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
IPR016275 Glucose-6-phosphatase
PFAM PF01569
PRINTS
PIRSF PIRSF000905
SMART SM00014
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6NSQ9
PhosphoSite PhosphoSite-Q6NSQ9
TrEMBL
UniProt Splice Variant
Entrez Gene 68401
UniGene Mm.22385
RefSeq NP_787949
MGI ID
MGI Symbol G6pc3
OMIM
CCDS CCDS25491
HPRD
IMGT
EMBL AK165395 AL954730 AY186239 BC069959
GenPept AAH69959 AAO39164 BAE38159 CAM25070

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca