InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd40

Summary

InnateDB Protein

IDBP-212535.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd40

Protein Name

CD40 antigen

Synonyms

AI326936; Bp50; GP39; HIGM1; IGM; IMD3; p50; T-BAM; Tnfrsf5; TRAP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000017799

InnateDB Gene

IDBG-212533 (Cd40)

Protein Structure

UniProt Annotation

Function

Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. {ECO:0000269PubMed:12881420}.

Subcellular Localization

Isoform I: Cell membrane; Single-pass type I membrane protein.Isoform III: Cell membrane; Single-pass type I membrane protein.Isoform IV: Cell membrane; Single-pass type I membrane protein.Isoform V: Cell membrane; Single-pass type I membrane protein.Isoform II: Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	43 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0002768	immune response-regulating cell surface receptor signaling pathway
GO:0006874	cellular calcium ion homeostasis
GO:0006954	inflammatory response
GO:0030890	positive regulation of B cell proliferation
GO:0032735	positive regulation of interleukin-12 production
GO:0032855	positive regulation of Rac GTPase activity
GO:0042113	B cell activation
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406	positive regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0050776	regulation of immune response
GO:0051023	regulation of immunoglobulin secretion
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051607	defense response to virus
GO:0071222	cellular response to lipopolysaccharide
GO:0071260	cellular response to mechanical stimulus
GO:0090037	positive regulation of protein kinase C signaling
GO:2000353	positive regulation of endothelial cell apoptotic process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0035631	CD40 receptor complex
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome