InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cd40

Summary

InnateDB Gene

IDBG-212533.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd40

Gene Name

CD40 antigen

Synonyms

AI326936; Bp50; GP39; HIGM1; IGM; IMD3; p50; T-BAM; Tnfrsf5; TRAP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017652

Encoded Proteins

IDBP-212535

CD40 antigen

IDBP-212537

CD40 antigen

IDBP-212539

CD40 antigen

IDBP-790408

CD40 antigen

IDBP-539009

CD40 antigen

IDBP-790410

CD40 antigen

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25549946

Tmem126a upregulates genes involved in antigen presentation; such as Icam1, MHC II, Cd86 and Cd40, via the Tlr4 signal transduction pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101017:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:165055627-165072948

Strand

Forward strand

Band

Transcripts

ENSMUST00000017799	ENSMUSP00000017799
ENSMUST00000073707	ENSMUSP00000073386
ENSMUST00000081310	ENSMUSP00000080059
ENSMUST00000154443	ENSMUSP00000138707
ENSMUST00000140951	ENSMUSP00000122981
ENSMUST00000153105
ENSMUST00000184221	ENSMUSP00000139193

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	43 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0002768	immune response-regulating cell surface receptor signaling pathway
GO:0006874	cellular calcium ion homeostasis
GO:0006954	inflammatory response
GO:0030890	positive regulation of B cell proliferation
GO:0032735	positive regulation of interleukin-12 production
GO:0032855	positive regulation of Rac GTPase activity
GO:0042113	B cell activation
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406	positive regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0050776	regulation of immune response
GO:0051023	regulation of immunoglobulin secretion
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051607	defense response to virus
GO:0071222	cellular response to lipopolysaccharide
GO:0071260	cellular response to mechanical stimulus
GO:0090037	positive regulation of protein kinase C signaling
GO:2000353	positive regulation of endothelial cell apoptotic process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0035631	CD40 receptor complex
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome