Version 5.4
Mus musculus Protein: Lsp1
Summary
InnateDB Protein IDBP-212563.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lsp1
Protein Name lymphocyte specific 1
Synonyms Lsp-1; p50; pp52; WP34;
Species Mus musculus
Ensembl Protein ENSMUSP00000018963
InnateDB Gene IDBG-212561 (Lsp1)
Protein Structure
UniProt Annotation
Function May play a role in mediating neutrophil activation and chemotaxis. {ECO:0000269PubMed:17481585}.
Subcellular Localization Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Disease Associations
Tissue Specificity Isoform 1 is expressed in normal mouse B and T-lymphocytes and in transformed B-cells but not (or in smaller amounts) in nine T-lymphoma lines tested. Isoform 2 is expressed in non-lymphoid cell lines (myocytes, stromal cells, fibroblasts).
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004871 signal transducer activity
Biological Process
GO:0006915 apoptotic process
GO:0006935 chemotaxis
GO:0006952 defense response
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:96832
InterPro IPR002211 Lymphocyte-specific protein
IPR006017 Caldesmon
IPR006018 Caldesmon/lymphocyte specific protein
PFAM PF02029
PRINTS PR01083
PR01076
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P19973
PhosphoSite PhosphoSite-P19973
TrEMBL
UniProt Splice Variant
Entrez Gene 16985
UniGene
RefSeq NP_001258452
MGI ID
MGI Symbol Lsp1
OMIM
CCDS CCDS52450
HPRD
IMGT
EMBL AK031587 AL603651 BC003796 D49691 M89956 M90316 S74179 U30939 U30940 U30941 U30942
GenPept AAA65108 AAB32257 AAB37542 AAB37543 AAB48537 AAH03796 BAA08541 BAC27463 CAM23282 CAM23283

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca