InnateDB Protein
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IDBP-212568.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Atxn7l3
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Protein Name
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ataxin 7-like 3
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000072967
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InnateDB Gene
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IDBG-212566 (Atxn7l3)
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Protein Structure
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Function |
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. {ECO:0000255HAMAP- Rule:MF_03047}.
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Subcellular Localization |
Nucleus {ECO:0000255HAMAP-Rule:MF_03047}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
13 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:3036270
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InterPro |
IPR013243
SCA7 domain
IPR013246
SAGA complex, Sgf11 subunit
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PFAM |
PF08313
PF08209
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A2AWT3
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PhosphoSite |
PhosphoSite-A2AWT3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
217218
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UniGene |
Mm.466283
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RefSeq |
NP_001092307
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MGI ID |
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MGI Symbol |
Atxn7l3
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OMIM |
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CCDS |
CCDS48941
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HPRD |
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IMGT |
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EMBL |
AK090368
AL954730
CH466558
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GenPept |
BAC41186
CAM25078
CAM25079
CAM25080
EDL34107
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