InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpm5

Summary

InnateDB Protein

IDBP-212685.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpm5

Protein Name

transient receptor potential cation channel, subfamily M, member 5

Synonyms

9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009390

InnateDB Gene

IDBG-212683 (Trpm5)

Protein Structure

UniProt Annotation

Function

Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage- dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals. {ECO:0000269PubMed:12842017, ECO:0000269PubMed:14657398, ECO:0000269PubMed:15731110, ECO:0000269PubMed:16355226, ECO:0000269PubMed:16436689, ECO:0000269PubMed:16935556, ECO:0000269PubMed:17267604, ECO:0000269PubMed:17522321}.

Subcellular Localization

Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000250UniProtKB:Q8TD43, ECO:0000255}.

Disease Associations

Tissue Specificity

Strongly expressed in liver, heart, testis, brain and kidney. Detected in fetal liver, kidney, spleen, brain, heart and lung, and in adult skin, eyes, spleen, stomach, small intestine, colon, lung, bladder, pancreas and thymus. Biallelically expressed at all stages and tissues examined. Also expressed in subsets of taste receptor cells of the tongue, in olfactory sensory neurons of the main olfactory epithelium and in the vomeronasal organ. {ECO:0000269PubMed:10903843, ECO:0000269PubMed:12368808, ECO:0000269PubMed:17267604, ECO:0000269PubMed:17610722}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005227	calcium activated cation channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005267	potassium channel activity
GO:0005272	sodium channel activity

Biological Process

GO:0006812	cation transport
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0045087	innate immune response (InnateDB)
GO:0071805	potassium ion transmembrane transport