InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnq1

Summary

InnateDB Protein

IDBP-212700.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnq1

Protein Name

potassium voltage-gated channel, subfamily Q, member 1

Synonyms

AW559127; Kcna9; KVLQT1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009689

InnateDB Gene

IDBG-212698 (Kcnq1)

Protein Structure

UniProt Annotation

Function

Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, kidney and salivary glands. Detected in the cochlea. Almost undetectable in brain, skeletal muscle and liver. Widely expressed in embryonic and neonatal tissues. {ECO:0000269PubMed:9618174}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008157	protein phosphatase 1 binding
GO:0015271	outward rectifier potassium channel activity
GO:0034236	protein kinase A catalytic subunit binding
GO:0034237	protein kinase A regulatory subunit binding
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding
GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
GO:0097110	scaffold protein binding
GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Biological Process

GO:0006349	regulation of gene expression by genetic imprinting
GO:0006811	ion transport
GO:0008584	male gonad development
GO:0016458	gene silencing
GO:0035690	cellular response to drug
GO:0046676	negative regulation of insulin secretion
GO:0055085	transmembrane transport
GO:0060048	cardiac muscle contraction
GO:0060306	regulation of membrane repolarization
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization
GO:0060454	positive regulation of gastric acid secretion
GO:0071320	cellular response to cAMP
GO:0071435	potassium ion export
GO:0071805	potassium ion transmembrane transport
GO:0072358	cardiovascular system development
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086011	membrane repolarization during action potential
GO:0086013	membrane repolarization during cardiac muscle cell action potential
GO:0086014	atrial cardiac muscle cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:1901381	positive regulation of potassium ion transmembrane transport

Cellular Component

GO:0005764	lysosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0042383	sarcolemma
GO:0042589	zymogen granule membrane

Protein Structure and Domains

PDB ID

MGI:108083

InterPro

IPR003091 Potassium channel
IPR003937 Potassium channel, voltage dependent, KCNQ
IPR005821 Ion transport domain
IPR005827 Potassium channel, voltage dependent, KCNQ1
IPR013099 Two pore domain potassium channel domain
IPR013821 Potassium channel, voltage dependent, KCNQ, C-terminal

PFAM

PF00520
PF07885
PF03520

PRINTS

PR00169
PR01459
PR01460

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97414