Version 5.4
Mus musculus Protein: Slc13a3
Summary
InnateDB Protein IDBP-212718.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc13a3
Protein Name solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000029208
InnateDB Gene IDBG-212716 (Slc13a3)
Protein Structure
UniProt Annotation
Function High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Highly expressed in kidney, and at much lower levels in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015362 high affinity sodium:dicarboxylate symporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0006835 dicarboxylic acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2149635
InterPro IPR001898 Sodium/sulphate symporter
IPR004680 Citrate transporter-like domain
PFAM PF00939
PF03600
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91Y63
PhosphoSite PhosphoSite-Q91Y63
TrEMBL Q3UUJ6
UniProt Splice Variant
Entrez Gene 114644
UniGene Mm.250738
RefSeq NP_473396
MGI ID
MGI Symbol Slc13a3
OMIM
CCDS CCDS17081
HPRD
IMGT
EMBL AF306491 AK138344 BC026803 CH466551
GenPept AAH26803 AAK49898 BAE23629 EDL06463

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca