InnateDB Protein
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IDBP-21285.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DPH3
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Protein Name
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DPH3, KTI11 homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000373285
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InnateDB Gene
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IDBG-21283 (DPH3)
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Protein Structure
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Function |
Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000250}.Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5. {ECO:0000269PubMed:14527407, ECO:0000269PubMed:14980502}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:14980502}. Nucleus {ECO:0000269PubMed:14980502}.
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Disease Associations |
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Tissue Specificity |
Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung. {ECO:0000269PubMed:14527407, ECO:0000269PubMed:14980502}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0017183
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peptidyl-diphthamide biosynthetic process from peptidyl-histidine
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GO:0050709
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negative regulation of protein secretion
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GO:0051099
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positive regulation of binding
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Cellular Component |
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PDB ID |
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InterPro |
IPR007872
Zinc finger, DPH-type
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PFAM |
PF05207
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96FX2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
285381
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UniGene |
Hs.612460
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RefSeq |
NP_001040899
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HUGO |
HGNC:27717
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OMIM |
608959
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CCDS |
CCDS43058
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HPRD |
16412
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IMGT |
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EMBL |
AK022970
BC010181
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GenPept |
AAH10181
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