Version 5.4
Homo sapiens Gene: DPH3
Summary
InnateDB Gene IDBG-21283.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPH3
Gene Name DPH3, KTI11 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154813
Encoded Proteins
IDBP-21285
DPH3, KTI11 homolog (S. cerevisiae)
IDBP-483518
DPH3, KTI11 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:16257978-16264972
Strand Reverse strand
Band p25.1
Transcripts
ENST00000383775 ENSP00000373285
ENST00000285082
ENST00000488423 ENSP00000419599
ENST00000462982
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0050709 negative regulation of protein secretion
GO:0051099 positive regulation of binding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021905
View Gene Order
ENSBTAG00000003916
Not yet available
Cross-References
SwissProt Q96FX2
TrEMBL A0A024R2P5
UniProt Splice Variant
Entrez Gene 285381
UniGene Hs.388087 Hs.612460
RefSeq NM_001047434 NM_206831
HUGO HGNC:27717
OMIM 608959
CCDS CCDS2629 CCDS43058
HPRD
IMGT
EMBL AK022970 BC010181 CH471055
GenPept AAH10181 EAW64268 EAW64269
RNA Seq Atlas 285381

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca