InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prex1

Summary

InnateDB Protein

IDBP-212887.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prex1

Protein Name

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037180

InnateDB Gene

IDBG-212885 (Prex1)

Protein Structure

UniProt Annotation

Function

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005543	phospholipid binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0030217	T cell differentiation
GO:0030593	neutrophil chemotaxis
GO:0030833	regulation of actin filament polymerization
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0045785	positive regulation of cell adhesion
GO:0050773	regulation of dendrite development
GO:0072593	reactive oxygen species metabolic process
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030426	growth cone
GO:0043198	dendritic shaft
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm