InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prex1

Summary

InnateDB Gene

IDBG-212885.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prex1

Gene Name

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039621

Encoded Proteins

IDBP-212887

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

IDBP-212889

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

IDBP-262799

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124126:
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:166566342-166713832

Strand

Reverse strand

Band

Transcripts

ENSMUST00000036719	ENSMUSP00000037180
ENSMUST00000099080	ENSMUSP00000096679
ENSMUST00000109246	ENSMUSP00000104869
ENSMUST00000136974
ENSMUST00000136564
ENSMUST00000152238
ENSMUST00000127553
ENSMUST00000140624

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005543	phospholipid binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0030217	T cell differentiation
GO:0030593	neutrophil chemotaxis
GO:0030833	regulation of actin filament polymerization
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0045785	positive regulation of cell adhesion
GO:0050773	regulation of dendrite development
GO:0072593	reactive oxygen species metabolic process
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030426	growth cone
GO:0043198	dendritic shaft
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000124126

View Gene Order

ENSBTAG00000015609

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04062

Chemokine signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04062

Chemokine signaling pathway pathway

INOH

PID NCI

rac1_reg_pathway

Regulation of RAC1 activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.489669

RefSeq

NM_177782

OMIM

CCDS

CCDS38334

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas