Version 5.4
Mus musculus Protein: Prex1
Summary
InnateDB Protein IDBP-212889.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Prex1
Protein Name phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000096679
InnateDB Gene IDBG-212885 (Prex1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0030217 T cell differentiation
GO:0030593 neutrophil chemotaxis
GO:0030833 regulation of actin filament polymerization
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0045785 positive regulation of cell adhesion
GO:0050773 regulation of dendrite development
GO:0072593 reactive oxygen species metabolic process
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030426 growth cone
GO:0043198 dendritic shaft
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:3040696
InterPro IPR000219 Dbl homology (DH) domain
IPR000591 DEP domain
IPR001478 PDZ domain
IPR001849 Pleckstrin homology domain
PFAM PF00621
PF00610
PF00595
PF13180
PF00169
PRINTS
PIRSF
SMART SM00325
SM00049
SM00228
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL I7HPV9
UniProt Splice Variant
Entrez Gene 277360
UniGene Mm.489669
RefSeq
MGI ID
MGI Symbol Prex1
OMIM
CCDS
HPRD
IMGT
EMBL AL591884 AL732357
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca