InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plcd3

Summary

InnateDB Protein

IDBP-212900.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plcd3

Protein Name

phospholipase C, delta 3

Synonyms

2610205J15Rik; mKIAA1964;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099366

InnateDB Gene

IDBG-212898 (Plcd3)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. {ECO:0000269PubMed:16314520}.

Subcellular Localization

Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Cleavage furrow. Note=Localizes at the cleavage furrow during cytokinesis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0001525	angiogenesis
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction
GO:0042127	regulation of cell proliferation
GO:0060716	labyrinthine layer blood vessel development

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0032154	cleavage furrow

Protein Structure and Domains

PDB ID

MGI:107451

InterPro

IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM

PF00168
PF00388
PF00387
PF00169
PF09279

PRINTS

PR00360
PR00390

PIRSF

SMART

SM00239
SM00148
SM00149
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt