InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fadd

Summary

InnateDB Protein

IDBP-212912.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fadd

Protein Name

Fas (TNFRSF6)-associated via death domain

Synonyms

Mort1/FADD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033394

InnateDB Gene

IDBG-212910 (Fadd)

Protein Structure

UniProt Annotation

Function

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005123	death receptor binding
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0032813	tumor necrosis factor receptor superfamily binding
GO:0035877	death effector domain binding
GO:0042802	identical protein binding

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002821	positive regulation of adaptive immune response
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0030217	T cell differentiation
GO:0032729	positive regulation of interferon-gamma production
GO:0032757	positive regulation of interleukin-8 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0033077	T cell differentiation in thymus
GO:0036462	TRAIL-activated apoptotic signaling pathway
GO:0042104	positive regulation of activated T cell proliferation
GO:0042981	regulation of apoptotic process
GO:0043029	T cell homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045651	positive regulation of macrophage differentiation
GO:0045862	positive regulation of proteolysis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048535	lymph node development
GO:0048536	spleen development
GO:0048538	thymus development
GO:0048738	cardiac muscle tissue development
GO:0051291	protein heterooligomerization
GO:0051607	defense response to virus
GO:0060340	positive regulation of type I interferon-mediated signaling pathway
GO:0060546	negative regulation of necroptotic process
GO:0070236	negative regulation of activation-induced cell death of T cells
GO:0070265	necrotic cell death
GO:0071260	cellular response to mechanical stimulus
GO:0097049	motor neuron apoptotic process
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097202	activation of cysteine-type endopeptidase activity
GO:0097527	necroptotic signaling pathway
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000454	positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031264	death-inducing signaling complex
GO:0031265	CD95 death-inducing signaling complex
GO:0043005	neuron projection
GO:0043234	protein complex
GO:0044297	cell body
GO:0045121	membrane raft
GO:0097342	ripoptosome