Version 5.4
Mus musculus Gene: Fadd
Summary
InnateDB Gene IDBG-212910.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fadd
Gene Name Fas (TNFRSF6)-associated via death domain
Synonyms Mort1/FADD
Species Mus musculus
Ensembl Gene ENSMUSG00000031077
Encoded Proteins
IDBP-212912
Fas (TNFRSF6)-associated via death domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21183682
Fadd interacts with Trim21 to negatively regulate the late Ifna pathway in response to viral infections. Fadd enhances Trim21 ubiquitin ligase activity to repress Ifna activation in SeV infected cells. In addition, Fadd with Trim21 can ubiquitinate Irf7 and change its phosphorylation state, consequently interfering with the activity of Traf6.
PMID 21804564
Fadd preserves epithelial barrier integrity and antibacterial defence, maintains homeostasis and prevents chronic intestinal inflammation.
PMID 21979465
Upon cleavage, Fadd oligomerizes and activates the caspase cascade to induce killing of tumour cells and intracellular pathogens by innate effector natural killer cells. (Demonstrated in human)
PMID 22000287
Fadd deficiency induces severe inflammatory skin lesions in mice, revealing a protective role for Fadd in epidermal keratinocytes.
InnateDB Annotation from Orthologs
Summary
PMID 17785432
[Homo sapiens] FADD is an adaptor protein involved in death receptor-mediated apoptosis and a physiological negative regulator of IRAK1/MyD88-dependent responses in innate immune signalling.
PMID 15711932
[Homo sapiens] FADD is part of the viral product dsRNA-triggered death inducing signalling complexes (dsRNA-DISCs) containing TRADD and CASP8.
PMID 21183682
[Homo sapiens] FADD interacts with TRIM21 to negatively regulate the late IFNA pathway in response to viral infections. FADD enhances TRIM21 ubiquitin ligase activity to repress IFNA activation in SeV infected cells. In addition, FADD with TRIM21 can ubiquitinate IRF7 and change its phosphorylation state, consequently interfering with the activity of TRAF6.
PMID 21804564
[Homo sapiens] FADD preserves epithelial barrier integrity and antibacterial defence, maintains homeostasis and prevents chronic intestinal inflammation. (Demonstrated in mouse)
PMID 21979465
[Homo sapiens] Upon cleavage, FADD oligomerizes and activates the caspase cascade to induce killing of tumour cells and intracellular pathogens by innate effector natural killer cells.
PMID 22000287
[Homo sapiens] FADD deficiency induces severe inflammatory skin lesions in mice, revealing a protective role for FADD in epidermal keratinocytes. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168040:
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:144577318-144582463
Strand Reverse strand
Band F5
Transcripts
ENSMUST00000033394 ENSMUSP00000033394
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 80 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005123 death receptor binding
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0032813 tumor necrosis factor receptor superfamily binding
GO:0035877 death effector domain binding
GO:0042802 identical protein binding
Biological Process
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002821 positive regulation of adaptive immune response
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0030217 T cell differentiation
GO:0032729 positive regulation of interferon-gamma production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033077 T cell differentiation in thymus
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0042104 positive regulation of activated T cell proliferation
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0045651 positive regulation of macrophage differentiation
GO:0045862 positive regulation of proteolysis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048535 lymph node development
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048738 cardiac muscle tissue development
GO:0051291 protein heterooligomerization
GO:0051607 defense response to virus
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0060546 negative regulation of necroptotic process
GO:0070236 negative regulation of activation-induced cell death of T cells
GO:0070265 necrotic cell death
GO:0071260 cellular response to mechanical stimulus
GO:0097049 motor neuron apoptotic process
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097202 activation of cysteine-type endopeptidase activity
GO:0097527 necroptotic signaling pathway
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000454 positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0043005 neuron projection
GO:0043234 protein complex
GO:0044297 cell body
GO:0045121 membrane raft
GO:0097342 ripoptosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000168040
View Gene Order
ENSBTAG00000018274
Not yet available
Pathways
NETPATH
REACTOME
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_258521
Apoptosis pathway
REACT_243608
Dimerization of procaspase-8 pathway
REACT_230745
Immune System pathway
REACT_241657
Caspase-8 activation by cleavage pathway
REACT_253999
TRAIL signaling pathway
REACT_263715
FasL/ CD95L signaling pathway
REACT_257735
Death Receptor Signalling pathway
REACT_215122
Regulation by c-FLIP pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_196636
TRIF-mediated programmed cell death pathway
REACT_205717
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
REACT_259850
Extrinsic Pathway for Apoptosis pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_241786
MyD88-independent cascade pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu05010
Alzheimer's disease pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu04210
Apoptosis pathway
mmu05200
Pathways in cancer pathway
mmu04622
RIG-I-like receptor signaling pathway pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
TNFR1 signaling pathway pathway
INOH website
Fas signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
NetPath_26
TWEAK pathway
REACTOME
REACT_25039
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_150361
TRIF-mediated programmed cell death pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_832
Dimerization of procaspase-8 pathway
REACT_1503
Caspase-8 activation by cleavage pathway
REACT_900
FasL/ CD95L signaling pathway
REACT_402
TRAIL signaling pathway
REACT_1059
Extrinsic Pathway for Apoptosis pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_578
Apoptosis pathway
REACT_6900
Immune System pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_164011
Regulation by c-FLIP pathway
REACT_1619
Death Receptor Signalling pathway
REACT_210286
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_227723
Extrinsic Pathway for Apoptosis pathway
REACT_224703
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_205566
Activated TLR4 signalling pathway
REACT_224546
MyD88-independent cascade pathway
REACT_221101
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_211168
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
REACT_213138
Immune System pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_211787
FasL/ CD95L signaling pathway
REACT_206178
Caspase-8 activation by cleavage pathway
REACT_226577
Dimerization of procaspase-8 pathway
REACT_260510
TRAIL signaling pathway
REACT_205393
TRIF-mediated programmed cell death pathway
REACT_216714
Innate Immune System pathway
REACT_215580
Death Receptor Signalling pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_213884
Regulation by c-FLIP pathway
REACT_219454
Apoptosis pathway
KEGG
hsa04210
Apoptosis pathway
hsa05010
Alzheimer's disease pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
INOH
INOH website
TNFR1 signaling pathway pathway
INOH website
Fas signaling pathway pathway
PID NCI
ceramide_pathway
Ceramide signaling pathway
caspase_pathway
Caspase Cascade in Apoptosis
tnfpathway
TNF receptor signaling pathway
trail_pathway
TRAIL signaling pathway
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
faspathway
FAS (CD95) signaling pathway
Cross-References
SwissProt Q61160
TrEMBL
UniProt Splice Variant
Entrez Gene 14082
UniGene Mm.5126
RefSeq NM_010175
OMIM
CCDS CCDS22050
HPRD
IMGT
MGI ID MGI:109324
MGI Symbol Fadd
EMBL AK084808 AK169798 AK170927 BC004584 BC021400 U43184 U50406
GenPept AAA97876 AAB07789 AAH04584 AAH21400 BAC39283 BAE41374 BAE42120
RNA Seq Atlas 14082

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca