Version 5.4
| Mus musculus Protein: Arhgap27 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-213023.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Arhgap27 | ||||||||
| Protein Name | Rho GTPase activating protein 27 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000039427 | ||||||||
| InnateDB Gene | IDBG-213021 (Arhgap27) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Widely expressed. Highly expressed in kidney, lung, small intestine and thymus. {ECO:0000269PubMed:15147912}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1916903 | ||||||||
| InterPro |
IPR000198
Rho GTPase-activating protein domain IPR001202 WW domain IPR001849 Pleckstrin homology domain IPR008936 Rho GTPase activation protein |
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| PFAM |
PF00620
PF00397 PF00169 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00324
SM00456 SM00233 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | A2AB59 | ||||||||
| PhosphoSite | PhosphoSite-A2AB59 | ||||||||
| TrEMBL | E9Q6V8 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 544817 | ||||||||
| UniGene | Mm.397197 | ||||||||
| RefSeq | NP_598476 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Arhgap27 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS25517 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK046763 AL662804 AL772325 BC096671 | ||||||||
| GenPept | AAH96671 BAE20660 CAM16599 CAM21566 | ||||||||