InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc9a8

Summary

InnateDB Protein

IDBP-213040.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc9a8

Protein Name

solute carrier family 9 (sodium/hydrogen exchanger), member 8

Synonyms

1200006P13Rik; 6430709P13Rik; AI182282; NHE8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044185

InnateDB Gene

IDBG-213038 (Slc9a8)

Protein Structure

UniProt Annotation

Function

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Expressed in both renal cortex and medulla. In the cortex, present in the majority of cortical tubules. In the medulla, most highly expressed in the proximal tubules (S3) of the outer stripe of the outer medulla. {ECO:0000269PubMed:12409279}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015299	solute:proton antiporter activity
GO:0015385	sodium:proton antiporter activity
GO:0015386	potassium:hydrogen antiporter activity

Biological Process

GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0006885	regulation of pH
GO:0035725	sodium ion transmembrane transport
GO:0051453	regulation of intracellular pH
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport
GO:1902600	hydrogen ion transmembrane transport