Mus musculus Gene: Slc9a8
Summary
InnateDB Gene IDBG-213038.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc9a8
Gene Name solute carrier family 9 (sodium/hydrogen exchanger), member 8
Synonyms 1200006P13Rik; 6430709P13Rik; AI182282; NHE8
Species Mus musculus
Ensembl Gene ENSMUSG00000039463
Encoded Proteins
solute carrier family 9 (sodium/hydrogen exchanger), member 8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197818:
Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:167421712-167477000
Strand Forward strand
Band H3
Transcripts
ENSMUST00000047815 ENSMUSP00000044185
ENSMUST00000073873 ENSMUSP00000073536
ENSMUST00000109218 ENSMUSP00000104841
ENSMUST00000150326
ENSMUST00000135353
ENSMUST00000131956
ENSMUST00000124139
ENSMUST00000141400
ENSMUST00000139673
ENSMUST00000149607
ENSMUST00000125855
ENSMUST00000155585
ENSMUST00000148454
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015299 solute:proton antiporter activity
GO:0015385 sodium:proton antiporter activity
GO:0015386 potassium:hydrogen antiporter activity
Biological Process
GO:0006812 cation transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006885 regulation of pH
GO:0035725 sodium ion transmembrane transport
GO:0051453 regulation of intracellular pH
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
SLC-mediated transmembrane transport pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
Transmembrane transport of small molecules pathway
Sodium/Proton exchangers pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Sodium/Proton exchangers pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
Transmembrane transport of small molecules pathway
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.278924 Mm.447861 Mm.463379
RefSeq NM_148929 NM_178371 XM_006500395 XM_006500396 XM_006500400
OMIM
CCDS CCDS38339 CCDS38340
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas