InnateDB Protein
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IDBP-213042.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slc9a8
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Protein Name
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solute carrier family 9 (sodium/hydrogen exchanger), member 8
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Synonyms
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1200006P13Rik; 6430709P13Rik; AI182282; NHE8;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000073536
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InnateDB Gene
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IDBG-213038 (Slc9a8)
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Protein Structure
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Function |
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity). {ECO:0000250}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. Expressed in both renal cortex and medulla. In the cortex, present in the majority of cortical tubules. In the medulla, most highly expressed in the proximal tubules (S3) of the outer stripe of the outer medulla. {ECO:0000269PubMed:12409279}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0015299
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solute:proton antiporter activity
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GO:0015385
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sodium:proton antiporter activity
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GO:0015386
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potassium:hydrogen antiporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1924281
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InterPro |
IPR004709
Na+/H+ exchanger
IPR006153
Cation/H+ exchanger
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PFAM |
PF00999
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PRINTS |
PR01084
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R4D1
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PhosphoSite |
PhosphoSite-Q8R4D1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
77031
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UniGene |
Mm.463379
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RefSeq |
NP_848458
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MGI ID |
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MGI Symbol |
Slc9a8
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OMIM |
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CCDS |
CCDS38340
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HPRD |
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IMGT |
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EMBL |
AB089793
AF482993
AK051791
AK129013
AK143281
AL589870
AL591762
BC030879
BC058947
CH466551
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GenPept |
AAH30879
AAH58947
AAL89753
BAC34770
BAC87669
BAD69591
BAE25331
CAM13827
EDL06513
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