InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pard6b

Summary

InnateDB Protein

IDBP-213104.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pard6b

Protein Name

par-6 (partitioning defective 6) homolog beta (C. elegans)

Synonyms

AV025615; Par6b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052619

InnateDB Gene

IDBG-213102 (Pard6b)

Protein Structure

UniProt Annotation

Function

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. {ECO:0000269PubMed:10934474, ECO:0000269PubMed:11839275}.

Subcellular Localization

Cytoplasm. Cell membrane. Cell junction, tight junction. Note=Colocalizes with active form of CDC42 or RAC1 at membrane ruffles. Also localizes to tight junctions.

Disease Associations

Tissue Specificity

Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006461	protein complex assembly
GO:0007049	cell cycle
GO:0051301	cell division

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0005938	cell cortex
GO:0043234	protein complex
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome