InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfatc2

Summary

InnateDB Protein

IDBP-213138.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfatc2

Protein Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

Synonyms

AI607462; NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029057

InnateDB Gene

IDBG-213130 (Nfatc2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	13 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001816	cytokine production
GO:0006355	regulation of transcription, DNA-templated
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030529	ribonucleoprotein complex
GO:0044798	nuclear transcription factor complex

Protein Structure and Domains

PDB ID

MGI:102463

InterPro

IPR008366 Nuclear factor of activated T cells (NFAT)
IPR008967 p53-like transcription factor, DNA-binding
IPR011539 Rel homology domain
IPR014756 Immunoglobulin E-set

PFAM

PF00554

PRINTS

PR01789

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite