InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itgb3

Summary

InnateDB Protein

IDBP-213177.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itgb3

Protein Name

integrin beta 3

Synonyms

CD61; GP3A; INGRB3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021028

InnateDB Gene

IDBG-213175 (Itgb3)

Protein Structure

UniProt Annotation

Function

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0007044	cell-substrate junction assembly
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0030334	regulation of cell migration
GO:0030335	positive regulation of cell migration
GO:0033690	positive regulation of osteoblast proliferation
GO:0045672	positive regulation of osteoclast differentiation
GO:0045780	positive regulation of bone resorption
GO:0048858	cell projection morphogenesis
GO:0060055	angiogenesis involved in wound healing
GO:0070527	platelet aggregation

Cellular Component

GO:0005634	nucleus
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0034679	alpha9-beta1 integrin complex
GO:0043235	receptor complex
GO:0071133	alpha9-beta1 integrin-ADAM8 complex

Protein Structure and Domains

PDB ID

MGI:96612

InterPro

IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR012896 Integrin beta subunit, tail
IPR013111 EGF-like domain, extracellular
IPR014836 Integrin beta subunit, cytoplasmic domain
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold

PFAM

PF00092
PF00362
PF07965
PF07974
PF08725

PRINTS

PR01186

PIRSF

PIRSF002512

SMART

SM00327
SM00187
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References