Version 5.4
Mus musculus Gene: Itgb3
Summary
InnateDB Gene IDBG-213175.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itgb3
Gene Name integrin beta 3
Synonyms CD61; GP3A; INGRB3
Species Mus musculus
Ensembl Gene ENSMUSG00000020689
Encoded Proteins
IDBP-213177
integrin beta 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23150579
[Homo sapiens] ITGAV::ITGB3 is a sensor and activator of innate immunity to herpes simplex virus-1.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000259207:
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:104608000-104670476
Strand Forward strand
Band E1
Transcripts
ENSMUST00000021028 ENSMUSP00000021028
ENSMUST00000127140
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005178 integrin binding
GO:0005515 protein binding
Biological Process
GO:0007044 cell-substrate junction assembly
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007275 multicellular organismal development
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0033690 positive regulation of osteoblast proliferation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045780 positive regulation of bone resorption
GO:0048858 cell projection morphogenesis
GO:0060055 angiogenesis involved in wound healing
GO:0070527 platelet aggregation
Cellular Component
GO:0005634 nucleus
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0034679 alpha9-beta1 integrin complex
GO:0043235 receptor complex
GO:0071133 alpha9-beta1 integrin-ADAM8 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000259207
View Gene Order
ENSBTAG00000009987
Not yet available
Pathways
NETPATH
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_196644
Syndecan interactions pathway
REACT_224553
Hemostasis pathway
REACT_227951
Signaling by VEGF pathway
REACT_198996
Elastic fibre formation pathway
REACT_198998
Molecules associated with elastic fibres pathway
REACT_206066
Extracellular matrix organization pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_238268
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_215461
Signal transduction by L1 pathway
REACT_219680
L1CAM interactions pathway
REACT_188576
Developmental Biology pathway
REACT_196606
ECM proteoglycans pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
REACT_240371
p130Cas linkage to MAPK signaling for integrins pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_188257
Signal Transduction pathway
REACT_246176
Integrin alphaIIb beta3 signaling pathway
REACT_249309
Platelet Aggregation (Plug Formation) pathway
KEGG
mmu04512
ECM-receptor interaction pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04510
Focal adhesion pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
mmu04380
Osteoclast differentiation pathway
mmu04145
Phagosome pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_24
TSLP pathway
REACTOME
REACT_12519
PECAM1 interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_15443
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
REACT_15381
p130Cas linkage to MAPK signaling for integrins pathway
REACT_15523
Integrin alphaIIb beta3 signaling pathway
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_118779
Extracellular matrix organization pathway
REACT_12529
Signaling by VEGF pathway
REACT_163942
Syndecan interactions pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_163906
ECM proteoglycans pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04640
Hematopoietic cell lineage pathway
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
hsa04380
Osteoclast differentiation pathway
hsa04145
Phagosome pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
avb3_integrin_pathway
Integrins in angiogenesis
integrin_cs_pathway
Integrin family cell surface interactions
ptp1bpathway
Signaling events mediated by PTP1B
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
nectin_pathway
Nectin adhesion pathway
ephrinbrevpathway
Ephrin B reverse signaling
il4_2pathway
IL4-mediated signaling events
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
integrin3_pathway
Beta3 integrin cell surface interactions
pdgfrbpathway
PDGFR-beta signaling pathway
arf6_pathway
Arf6 signaling events
avb3_opn_pathway
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.87150
RefSeq NM_016780 XM_006532312
OMIM
CCDS CCDS25536
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca