InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mc3r

Summary

InnateDB Protein

IDBP-213277.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mc3r

Protein Name

melanocortin 3 receptor

Synonyms

MC3-R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047358

InnateDB Gene

IDBG-213275 (Mc3r)

Protein Structure

UniProt Annotation

Function

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004977	melanocortin receptor activity
GO:0004980	melanocyte-stimulating hormone receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0042923	neuropeptide binding

Biological Process

GO:0002027	regulation of heart rate
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0008217	regulation of blood pressure
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0042309	homoiothermy
GO:0055078	sodium ion homeostasis

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96929

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001671 Melanocortin/ACTH receptor
IPR001908 Melanocortin receptor
IPR002122 Melanocortin 3 receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00534
PR00535
PR01061

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P33033