InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mc3r

Summary

InnateDB Gene

IDBG-213275.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mc3r

Gene Name

melanocortin 3 receptor

Synonyms

MC3-R

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038537

Encoded Proteins

IDBP-213277

melanocortin 3 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis and adaptation to food restriction. Disruption of this gene results in an increased ratio of weight gain to food intake, increased fat mass, and decreased lean mass, without having a large effect on insulin sensitivity or glucose metabolism. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:172248492-172251114

Strand

Forward strand

Band

Transcripts

ENSMUST00000038532

ENSMUSP00000047358

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004977	melanocortin receptor activity
GO:0004980	melanocyte-stimulating hormone receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0042923	neuropeptide binding

Biological Process

GO:0002027	regulation of heart rate
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0008217	regulation of blood pressure
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0042309	homoiothermy
GO:0055078	sodium ion homeostasis