InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ace

Summary

InnateDB Protein

IDBP-213295.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ace

Protein Name

angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

Synonyms

AW208573; CD143;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001963

InnateDB Gene

IDBG-213293 (Ace)

Protein Structure

UniProt Annotation

Function

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm. {ECO:0000269PubMed:15665832, ECO:0000269PubMed:7753170, ECO:0000269PubMed:8642790}.

Subcellular Localization

Angiotensin-converting enzyme, soluble form: Secreted {ECO:0000250}.Cell membrane {ECO:0000269PubMed:23535237}; Single-pass type I membrane protein {ECO:0000269PubMed:23535237}. Cytoplasm {ECO:0000269PubMed:23535237}. Note=Detected in both cell membrane and cytoplasm in neurons.

Disease Associations

Tissue Specificity

Testis-specific isoform is expressed in spermatocytes, adult testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008241	peptidyl-dipeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0001822	kidney development
GO:0002446	neutrophil mediated immunity
GO:0003084	positive regulation of systemic arterial blood pressure
GO:0006508	proteolysis
GO:0007283	spermatogenesis
GO:0008217	regulation of blood pressure
GO:0042447	hormone catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0060047	heart contraction